Isopropanol → 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether

HRID 233229

反応式

HRID 233229 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.O1CC1C[C:20]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:21]=1[O:28][C:29]1[CH:34]=[CH:33]C(OC)=CC=1CC1OC1.C([OH:45])(C)C>>[CH3:27][O:26][C:24]1[CH:25]=[CH:20][C:21]([O:28][CH2:29][CH:34]([OH:45])[CH2:33][N:12]2[CH2:11][CH2:10][CH:9]([C:6]3[C:5]4[CH:15]=[CH:16][C:2]([F:1])=[CH:3][C:4]=4[O:8][N:7]=3)[CH2:14][CH2:13]2)=[CH:22][CH:23]=1

参加物

4

反応物 3

HCID 3776IsopropanolHCID 8494213-(4-Piperidyl)-6-fluoro-1,2-benzisoxazoleHCID 199644222,3-Epoxypropyl4-methoxyphenyl ether

生成物 1

HCID 184672574-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether

実験手順

A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (4.4 g, 20 mmol) and 2,3-epoxypropyl-4-methoxyphenyl ether (3.7 g, 20.5 mmol) in isopropyl alcohol (80 ml) was heated to reflux for 2 hours. The mixture was cooled and the crystals were collected to yield 6.81 g (85%), m.p.=134°-135° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe mixture was cooled
  4. customthe crystals were collected
  5. customto yield 6.81 g (85%), m.p.=134°-135° C.

出典と根拠

ORDレコード
ord-1c9f11401c1f4f84b0276732a64bc5d9
出典データセット
uspto-grants-1997_01
特許番号
US05591745

関連ノート

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