関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Carbamic acid, ethyl ester | HCID 5641 | — |
| 反応物 | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| 反応物 | HCID 178418385 | HCID 178418385 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethoxycarbonyl-(1-benzotriazolyl)glycine | HCID 53982471 | 96% |
反応手順
Ethyl carbamate (69.0 g, 774.5 mmol), glyoxylic acid hydrate (71.3 g, 774.5 mmol) and benzotriazole (92.0 g, 774.5 mmol) were dissolved in toluene (2.3 1) and the mixture was heated with distillation for 3 h to precipitate the product. The mixture was diluted with toluene (totally 2.3 1) and stirred at 15° C. overnight. The resultant precipitate was collected by filtration, washed with toluene (160 ml) and dried to afford the title compound (196.06 g, 96%): mp. 189°-192° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728829 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-5df61b0f843d454b91abd7c3ea08a12b |
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| 出典メモ | uspto-grants-1998_03 |
|---|
