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HRID 23398作成日：2026年10月24日
5-chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-[2-(tetrahydro-pyran-2-yloxy)-ethanesulfonyl]-1H-indole → 2-[5-Chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1H-indole-3-sulfonyl]-ethanol
https://huagongshe.com/ja/reaction/23398
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
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| 反応物 | 5-chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-[2-(tetrahydro-pyran-2-yloxy)-ethanesulfonyl]-1H-indole | HCID 22573990 | — |
| 溶媒 | Acetic acid--water (1/1) | HCID 21899381 | — |
| 生成物 | 2-[5-Chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1H-indole-3-sulfonyl]-ethanol | HCID 22574068 | — |
反応手順
The 5-chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-[2-(tetrahydro-pyran-2-yloxy)-ethanesulfonyl]-1H-indole (0.028 g) prepared in the previous Step was dissolved in 4 ml acetic acid:water (2:1) and stirred at 45-50° C. for 3 h. The solvents were removed under reduced pressure and the crude product was purified by column chromatography (silica gel) eluting with 3-5% methanol in methylene chloride with 0.1% ammonium hydroxide added. The 2-[5-Chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1H-indole-3-sulfonyl]-ethanol thus obtained weighed 0.005 g after drying.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06852726B2 |
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| 出典データセット | uspto-grants-2005_02 |
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| ORD ID | ord-99f5b152a87f44f1b7471a0d3254f0ff |
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| 出典メモ | uspto-grants-2005_02 |
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