化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 5-hydroxypent-2-ynoate → (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-(2-hydroxy-ethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 5-hydroxypent-2-ynoate | HCID 15057368 | — |
| 反応物 | (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 66875140 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-(2-hydroxy-ethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one | HCID 25073304 | — |
反応手順
The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 5-hydroxy-pent-2-ynoic acid ethyl ester employing the procedure described in Example 105. [αa]D25 +6.40 (c 0.5, DMSO).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642603B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-5d2f91b2aeaa431a9eddda3a700d6889 |
| 出典メモ | uspto-grants-2014_02 |