化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → 1-Methyl-4-piperidinemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | 4-Piperidinemethanol | HCID 420771 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-Methyl-4-piperidinemethanol | HCID 271971 | — |
反応手順
To a solution of 4-piperidylmethanol (1.0 g, 8.7 mmol) and HCHO (2 mL, 25 mmol, 37% in H2O) in CH3CN was added NaCNBH3 (0.5 g, 12.5 mmol). The resulting mixture was stirred for 1 h and filtered. The filtrate was concentrated and the residue was distilled (105° C., 40 torr) to give the title intermediate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642624B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-cbf6007db3ec4fcd92703db4737489df |
| 出典メモ | uspto-grants-2014_02 |