化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromo-5-(ethylsulfonyl)pyridine → [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-3,6-difluoro-naphthalen-2-yl]-acetic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-5-(ethylsulfonyl)pyridine | HCID 53393184 | — |
| 反応物 | (3,6-Difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester | HCID 59326617 | — |
| 反応物 | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| 生成物 | [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-3,6-difluoro-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326477 | 48% |
反応手順
Starting with (3,6-difluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester (25 mg, 0.099 mmol) and 2-bromo-5-ethanesulfonyl-pyridine (28 mg, 0.112 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [4-(5-ethanesulfonyl-pyridin-2-yloxy)-3,6-difluoro-naphthalen-2-yl]-acetic acid methyl ester (20 mg, 48%) was obtained as a white solid, which was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642629B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-1ba199307a4f4c2e99abaff2eacf5524 |
| 出典メモ | uspto-grants-2014_02 |