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Hydrochloric Acid → 1003320-03-3
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate | HCID 7172298 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1003320-03-3 | HCID 86631242 | — |
反応手順
To a solution of 1,1-dimethylethyl 4-(4-formyl-2-thiazolyl)-1-piperidinecarboxylate (1.0 g, 3.4 mmol) in dichloromethane (20 mL) was added a solution of hydrogen chloride in diethyl ether (2.0 mL, 15 ml, 30 mmol). The reaction mixture was stirred under nitrogen at room temperature for 2 h and then evaporated under reduced pressure to give 1.2 g of the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642634B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-031bd07804ce4d2d89ecdaf770b44a56 |
| 出典メモ | uspto-grants-2014_02 |