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6-Chloro-3-nitropyridin-2-ylamine → 2-Amino-3-nitro-6-(phenylmercapto)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chloro-3-nitropyridin-2-ylamine | HCID 2724035 | — |
| 反応物 | Sodium benzenethiolate | HCID 4110039 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-Amino-3-nitro-6-(phenylmercapto)pyridine | HCID 11021215 | 95% |
反応手順
2-amino-3-nitro-6-(phenylmercapto)pyridine was prepared by heating 2-amino-6-chloro-3-nitropyridine (84.0 g, 0.484 mol) and sodium thiophenolate (Fluka) (72.0 g, 0.545 mol) in 2-propanol (1500 mL) under reflux for 2 hours. After cooling to room temperature the suspension was diluted with water (100 ml), the solid was collected by vacuum filtration, washed with water and 2-propanol, and dried at 50° C. under vacuum to give 109.1 g (95% yield) of 2-amino-3-nitro-6-(phenylmercapto)pyridine, m.p. 148-152° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855723B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-713806fd865b4bfbb75c2e6c2756ef9c |
| 出典メモ | uspto-grants-2005_02 |