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Imidazole → 5-Imidazol-1-ylmethyl-quinolin-8-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 8-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1) | HCID 12269596 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-Imidazol-1-ylmethyl-quinolin-8-ol | HCID 594190 | 29% |
反応手順
A mixture of 5-chloromethyl-8-hydroxyquinoline hydrochloride (3.45 g; 15 mmol), imidazole (1.02 g; 15 mmol) and diisopropylethylamine (5.25 ml; 30 mmol) in CHCl3 (60 ml) was stirred for 24 h at room temperature and then for 3 h at 60° C. After cooling, the mixture was evaporated, washed with ethyl acetate (50 ml) and then hexane (50 ml). The residue was crystallized from a mixture of toluene and ethanol (abs.) to give 0.83 g (29%) of title product. M.p. 182° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855711B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-1eb91e4390e4438fb90926e9ae38c271 |
| 出典メモ | uspto-grants-2005_02 |