4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid → HCID 178422964、化合物

HRID 2398237

反応式

HRID 2398237 の反応式
[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([C:12]([OH:14])=O)=[CH:8][NH:9]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1>CN(C)C=O>[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([C:12]([NH:16][C:17]3[NH:21][N:20]=[N:19][N:18]=3)=[O:14])=[CH:8][NH:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 53736724-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acidHCID 178509299HCID 178509299、化合物

生成物 1

HCID 178422964HCID 178422964、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (4 g) and N,N'-carbonyldiimidazole (3.5 g) in dimethylformamide (40 ml) were heated at 80° for 6 hours. 5-Amino-1H-tetrazole (2.5 g) was added and the mixture was stirred and heated at 80° for 1.5 hours. The solid was collected and dissolved in aqueous sodium hydroxide. The solution was acidified with glacial acetic acid and the solid was collected and dried. It had m.p. 344°-345.5°, (47%)

後処理

  1. temperatureheated at 80° for 1.5 hours
  2. customThe solid was collected
  3. dissolutiondissolved in aqueous sodium hydroxide
  4. customthe solid was collected
  5. customdried

出典と根拠

ORDレコード
ord-b4590d6fd806448088eb4623c006433b
出典データセット
uspto-grants-1977_05
特許番号
US04024255

関連ノート

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