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Hydrochloric Acid → 2-Hydroxymethylchrysene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium borohydride | HCID 4148881 | — |
| 反応物 | Ethyl chrysene-2-carboxylate | HCID 15599324 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Hydroxymethylchrysene | HCID 15599323 | 95% |
反応手順
Ethyl chrysene-2-carboxylate (20B, 10.1 g, 0.034 mol) in THF (500 mL) was treated with LiBH4 (Alfa, 4×0.5 g, 0.092 mol) under gentle reflux for 4 days. The reaction mixture was poured into ice and acidified carefully to pH 1 with 1M HCl. The precipitate was filtered and recrystallized from THF/hexane to afford 8.32 g (95%) of 2-chrysenemethanol mp 261°-262°, (C,H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04719048 |
| 出典データセット | uspto-grants-1988_01 |
| ORD ID | ord-e4649456c9be4fc89a8e1a5fe626fd69 |
| 出典メモ | uspto-grants-1988_01 |