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Phenyl formate → 5-((1H-Pyrrol-2-YL)methyl)-1H-pyrrole-2-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl formate | HCID 74626 | — |
| 反応物 | Dipyrromethane | HCID 140814 | — |
| 反応物 | HCID 178425415 | HCID 178425415 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Chlorin | HCID 65106 | — |
| 生成物 | 5-((1H-Pyrrol-2-YL)methyl)-1H-pyrrole-2-carbaldehyde | HCID 16732691 | — |
反応手順
As part of our work in chlorin chemistry, we recently developed an efficient route for the synthesis of 1-formyldipyrromethanes.21 The formylation method entailed traditional Vilsmeier formylation or treatment of a solution of dipyrromethane in THF at room temperature with 2 molar equiv of MesMgBr and then at −78° C. with 2 molar equiv of phenyl formate. The subsequent workup and column chromatography afforded the desired 1-formyldipyrromethane in good yields.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07964720B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-8981bbf13a2a446daccc74351713951b |
| 出典メモ | uspto-grants-2011_06 |