化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → N-methyl-2-oxoindoline-5-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 4962506 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-methyl-2-oxoindoline-5-sulfonamide | HCID 10176909 | 88% |
反応手順
A suspension of 3.38 g of 5-chlorosulfonyl-2-oxindole in 10 mL 2M methylamine in tetrahydrofuran was stirred at room temperature for 4 hours during which time a white solid formed. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855730B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-fe9bd36b9da843ffb41b3aaadcf3b7a7 |
| 出典メモ | uspto-grants-2005_02 |