化工社化工社 化学情報印刷レポート · 研究参考用
1H-Indazole → 5-isopropyl-1H-indazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-Indazole | HCID 9221 | — |
| 反応物 | 5-(prop-1-en-2-yl)-1H-indazole | HCID 86678017 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-isopropyl-1H-indazole | HCID 21338503 | — |
反応手順
A 2:3 mixture of 5-(prop-1-en-2-yl)-1H-indazole and 1H-indazole (0.9 g), 10% Pd/C (0.2 g) in 150 mL of methanol was stirred at room temperature under H2 balloon for 3 hours. Pd/C was filtered off and the filtrate was concentrated under reduced pressure to give crude 5-isopropyl-1H-indazole (0.85 g) as an oil. LCMS: (M+H)+=161.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08658646B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-d5f6ba35232842419c53522cde50bbfc |
| 出典メモ | uspto-grants-2014_02 |