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Diketene → Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diketene | HCID 12661 | — |
| 反応物 | 6-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one | HCID 676750 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide | HCID 13646979 | — |
反応手順
20 g (0.106 mole) of 3-(4-aminophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine in 250 ml of dimethylformamide are stirred with 9.47 g (0.113 moles) of diketene for 12 hours at room temperature. After the mixture has been concentrated, the residue is boiled up with 100 ml of ethanol, and the product is filtered off after cooling.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04707479 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-06341a1303b7490f95e684614b1007ea |
| 出典メモ | uspto-grants-1987_11 |