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1,4-Dichlorobenzene → (2,5-Dichlorophenyl)(3-methylphenyl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dichlorobenzene | HCID 4685 | — |
| 反応物 | 3-Methylbenzoyl chloride | HCID 74375 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 生成物 | (2,5-Dichlorophenyl)(3-methylphenyl)methanone | HCID 18704036 | 53% |
反応手順
The procedure of Example 2 was followed, using 22 ml (0.17 mol) of 3-toluoyl chloride and 60 g (0.45 mol) of aluminum chloride in 120 g (0.82 mol) of 1,4-dichlorobenzene. (The molar ratio of reactants was 2.6:4.8:1.0 (AlCl3 :Dichlorobenzene:3-Toluoyl Chloride)). Pure 2,5-dichloro-3'-methyl-benzophenone was isolated in 53% yield after the crude product was recrystallized twice from hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05210313 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-2624c3d956854183a95148f8c3cc395b |
| 出典メモ | uspto-grants-1993_05 |