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Ethyl 4-Chloroquinoline-3-carboxylate → Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-Chloroquinoline-3-carboxylate | HCID 268963 | — |
| 反応物 | Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate | HCID 178469538 | — |
| 生成物 | Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate | HCID 4322147 | — |
反応手順
The title compound was prepared following the procedure described in Step 2 for the synthesis of 3a using 2h instead of 2a. 1H NMR (CDCl3) δ (ppm): 1.46 (3H, t, J=7.14 Hz), 4.51 (2H, q, J=7.14 Hz), 8.00 (1H, dd, J=8.79, 1.92 Hz), 8.26 (1H, d, J=8.79 Hz), 8.78 (1H, dd, J=1.92, 0.83 Hz), 9.34 (1H, s). m/z 304.6 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863266B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-7836d803e22c4d1abc09c792d84da247 |
| 出典メモ | uspto-grants-2011_01 |