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Potassium Carbonate → (4-(2,6-Difluorobenzyloxy)phenyl)-acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Hydroxybenzyl cyanide | HCID 26548 | — |
| 反応物 | 2-(Bromomethyl)-1,3-difluorobenzene | HCID 581435 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (4-(2,6-Difluorobenzyloxy)phenyl)-acetonitrile | HCID 21964471 | — |
反応手順
To a solution of 4-Hydroxybenzyl cyanide (5 g, 37.5 mmol) and K2CO3 (6.74 g, 48.8 mmol) in dry DMF (20 ml) was added 2,6-Difluorobenzyl bromide (7.77 g, 37.5 mmol). The reaction mixture was stirred for 4 hours at room temperature and concentrated in vacuo. The crude residue was taken in EtOAc and washed with water and brine. The aqueous layer was washed one more time with EtOAc. The combined organic layers were dried over Na2SO4 filtered, and concentrated to provide the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858602B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-fae8d767f9e949d2abdb4e613181892b |
| 出典メモ | uspto-grants-2005_02 |