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1-(2-Chloro-4-fluorophenyl)cyclohexanecarboxylic acid → HCID 178441258、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Chloro-4-fluorophenyl)cyclohexanecarboxylic acid | HCID 1268166 | — |
| 反応物 | 2-tert-Butyl-4-butylisothiazol-5(2H)-imine | HCID 66867228 | — |
| 生成物 | HCID 178441258 | HCID 178441258 | — |
反応手順
The product from Example 92B and (2-chloro-4-fluorophenyl)cyclohexanecarboxylic acid (Acros) were processed using the method described in Example 92C to afford the title compound. 1H NMR (DMSO-d6) δ 0.76 (t, J=7.3 Hz, 3H), 1.06-1.18 (m, 2H), 1.33-1.53 (m, 8H), 1.56 (s, 9H), 1.71-1.81 (m, 2H), 1.92-2.00 (m, 2H), 2.34-2.42 (m, 2H), 7.14-7.22 (m, 2H), 7.57 (dd, J=8.6, 6.3 Hz, 1H), 8.46 (s, 1H). MS (ESI+) m/z 451 (M+H)+. Anal. calcd. for C24H32ClFN2OS: C, 63.91; H, 7.15; N, 6.21. Found: C, 64.04; H, 7.08; N, 6.10.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07872033B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-18875a6035b54c1795abf0e33acb9b47 |
| 出典メモ | uspto-grants-2011_01 |