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Succinic Acid → Succinimide succinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Succinic Acid | HCID 1110 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Succinic anhydride | HCID 7922 | — |
| 生成物 | Succinimide succinate | HCID 66685880 | — |
反応手順
As depicted in above Scheme 4, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with succinic reagents, e.g., succinic anhydride and toluene as solvent to synthesize 6-arm PEG-succinic acid (6-arm PEG-SA) (6). The 6-arm PEG SA (6) is reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide succinate (6-arm PEG-SS) (7).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858736B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-1a7ed486abdf44a381336bc9e5bad0ba |
| 出典メモ | uspto-grants-2005_02 |