化工社化工社 化学情報印刷レポート · 研究参考用
Water → Diethyl 4-isothiocyanatobenzylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Thiophosgene | HCID 10040 | — |
| 反応物 | Diethyl p-aminobenzylphosphonate | HCID 88358 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Diethyl 4-isothiocyanatobenzylphosphonate | HCID 22568434 | — |
反応手順
Thiophosgene (4.1 mL, 54 mmol) was added al at once to a mixture of diethyl 4-aminobenzylphosphonate (12.04 g, 50 mmol), sodium bicarbonate (8.33 g, 99 mmol), water (100 mL), and dichloromethane (250 mL), and the mixture was stirred at room temperature for about 2 hours. The organic and aqueous layers were separated, the organic layer dried over magnesium sulfate, filtered, and concentrated to give the product isothiocyanate as a brown oil. This was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858739B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-2c8f5600ae6f41b9984d67f20d309d62 |
| 出典メモ | uspto-grants-2005_02 |