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Pyridine → 1-(Benzyloxy)-2-(chloromethyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Salicyl Alcohol | HCID 5146 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Benzenemethanol, 2-(phenylmethoxy)- | HCID 18811 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-(Benzyloxy)-2-(chloromethyl)benzene | HCID 563507 | 81% |
反応手順
To a solution of 46.5 (0.217 mole) 2-benzyloxybenzyl alcohol (prepared by reaction of 2-hydroxybenzyl alcohol with benzyl chloride in ethanol containing an equimolar amount of potassium t-butoxide at 100° C.) in 100 ml chloroform was added 17.2 g (0.217 mole) pyridine followed by dropwise addition of a solution of 25.8 g (0.217 mole) thionyl chloride in 60 ml chloroform. The resulting mixture was heated at reflux for 1.5 hours, cooled, washed with water, brine and dried (MgSO4). Evaporation of solvent gave 45.8 g crude oil which was distilled in vacuo to yield 40.7 g (81%) of product as a colorless oil, b.p. 141° C.(1 Torr).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04703052 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-e57e3edb022740a8926893137e99290e |
| 出典メモ | uspto-grants-1987_10 |