関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Riluzole | HCID 5070 | — |
| 反応物 | 2-Bromoethanol | HCID 10898 | — |
| 反応物 | 3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline | HCID 3076252 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide | HCID 3076251 | — |
反応手順
2-(2-Imino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol may be prepared according to the following process: 2-amino-6-trifluoromethoxybenzothiazole (9.4 g) and 2-bromoethanol (10 g) in absolute ethanol (30 cc) are heated to boiling for 95 hours. The mixture is then cooled to a temperature in the region of 20° C. The precipitate formed is filtered off and washed with ethyl ether (100 cc). 2-(2-Imino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol hydrobromide (6.4 g), m.p. 219° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05260297 |
|---|
| 出典データセット | uspto-grants-1993_11 |
|---|
| ORD ID | ord-22f87acda8d64e5d9fdeebf053f554a8 |
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| 出典メモ | uspto-grants-1993_11 |
|---|
