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4-Phenylpiperidine-4-carboxamide monohydrochloride → 1-[2-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Phenylpiperidine-4-carboxamide monohydrochloride | HCID 3017129 | — |
| 反応物 | 2-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate | HCID 86750910 | — |
| 生成物 | 1-[2-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide | HCID 44319249 | — |
反応手順
Prepared by the methoB of example 3.3 using 2-[3-(3,4-dimethoxy-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (0.55 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (175 mg, 0.73 mmol). Chromatography on silica gel (30 g) eluting sequentially with ethyl acetate, 6% methanol in dichloromethane, and 10% methanol in dichloromethane gave the title compound:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648366 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-f75d72479db24e4b82ef24d9935e49a7 |
| 出典メモ | uspto-grants-1997_07 |