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Aminoacetaldehyde → 1-[alpha-(o-Chlorophenyl)-o-tolyl]imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aminoacetaldehyde | HCID 363 | — |
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | 2-[(2-Chlorophenyl)methyl]aniline | HCID 13426664 | — |
| 触媒 | Titanium Tetrachloride | HCID 24193 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 1-[alpha-(o-Chlorophenyl)-o-tolyl]imidazole | HCID 21497409 | — |
反応手順
In the manner given in Example 1, α-(0-chlorophenyl)-0-toluidine is reacted first with trimethyl orthoformate; the resulting product is reacted with aminoacetaldehyde, dimethyl acetal, and the resulting product of this reaction is heated with titanium tetrachloride in monoglyme to give 1-[α-(0-chlorophenyl)-0-tolyl]imidazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03941802 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-f06bfcfd0f2d436682cbfdbb504b6f16 |
| 出典メモ | uspto-grants-1976_03 |