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Toluene → Ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | Ethyl 4-oxo-1-piperidinecarboxylate | HCID 34767 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate | HCID 14665236 | — |
反応手順
A mixture of 171.2 parts of ethyl 4-oxo-1-piperidinecarboxylate, 159.5 parts of 4-chlorobenzeneamine, 1520 parts of anhydrous methylbenzene and a few crystals of 4-methylbenzenesulfonic acid is stirred and refluxed for 7 hours. (The reaction vessel is provided with a reflux-condensor and water-separator). The methylbenzene is evaporated and the oily residue is distilled in vacuo, yielding 192 parts of oily ethyl 4-[(4-chlorophenyl)imino]-1-piperidine-carboxylate; bp. 171°-176° C. at 0.4 mm. pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04151286 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-d57b5d7ea41b4259acc2bd37a7ee7e13 |
| 出典メモ | uspto-grants-1979_04 |