Dimethylformamide → HCID 178422953、化合物

HRID 267505

反応式

HRID 267505 の反応式
[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([C:12](O)=O)=[CH:8][NH:9]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1.CN(C)[CH:24]=[O:25]>>[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([CH2:12][C:24]([NH:16][C:17]3[NH:21][N:20]=[N:19][N:18]=3)=[O:25])=[CH:8][NH:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 53736724-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acidHCID 178509299HCID 178509299、化合物

生成物 1

HCID 178422953HCID 178422953、化合物

実験手順

1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (4 g) and N,N'-carbonyldiimidazole (3.5 g) in dimethylformamide (40 ml) were heated at 80° for 6 hours. 5-Amino-1H-tetrazole (2.5 g) was added and the mixture was stirred and heated at 80° for 1.5 hours. The solid was collected and dissolved in aqueous sodium hydroxide. The solution was acidified with glacial acetic acid and the solid was collected and dried. It had m.p. 344°-345.5°, (47%)

後処理

  1. temperatureheated at 80° for 1.5 hours
  2. customThe solid was collected
  3. dissolutiondissolved in aqueous sodium hydroxide
  4. customthe solid was collected
  5. customdried

出典と根拠

ORDレコード
ord-d798cd99aa324fcf9bd1f12ba2b3a220
出典データセット
uspto-grants-1976_03
特許番号
US03943141

関連ノート

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