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Sulfuric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 4-Hydroxy-2-Butanone | HCID 111509 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 反応物 | 1,1'-Biphenyl, 4'-bromo-2,4-difluoro- | HCID 21322611 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
反応手順
0.44 g. of 1 -hydroxy-3-butanone in 40 ml. of ether is added dropwise, at 20° to stirred Grignard solution obtained from 2.69 g. of 4-bromo-2',4'-difluorobiphenyl and 0.24 g. of magnesium in 100 ml. of ether. The mixture is stirred for two hours more and the resulting alcoholate is decomposed with dilute sulfuric acid. The ether phase is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04151302 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-d3e09d4998144f26af463aa41940b803 |
| 出典メモ | uspto-grants-1979_04 |