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Hexachloroethane → 4-Methoxy-3-methylbenzyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexachloroethane | HCID 6214 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | (4-Methoxy-3-methylphenyl)methanol | HCID 14457544 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Methoxy-3-methylbenzyl chloride | HCID 143742 | 100% |
反応手順
To a stirred solution of (4-methoxy-3-methylphenyl)methanol (2.31g, 15.18mmoles, 1eq) in anhydrous CH2Cl2(50ml, 0.3M) was added hexachloroethane (3.59g, 15.18mmoles, 1eq) and triphenylphosphine (3.98g, 15.18mmoles, 1eq). This mixture was stirred at room temperature overnight at which point the reaction was transferred to a separatory funnel and washed with H2O, brine, dried over Na2SO4, filtered, concentrated in vacuo and filtered through a plug of silica gel (30% EtOAc/Hexanes) to yield 2.59g (100%) of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07449468B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-b9176512d903468e9f304292a891a365 |
| 出典メモ | uspto-grants-2008_11 |