関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 反応物 | Methanesulfonic acid 2-(2-chloromethyl-phenyl)-ethyl ester | HCID 54328826 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-(Chloromethyl)-2-ethenylbenzene | HCID 89757 | 82% |
反応手順
Dissolve methanesulfonic acid 2-(2-chloromethyl-phenyl)-ethyl ester (8.8 g, 35.4 mmol) in ether (80 mL) and cool to -35° C. Add potassium t-butoxide (10 g, 89 mmol) and stir for 30 minutes. Add water (50 mL) and ether (150 mL), extract, dry (Na2SO4) and purify by silica gel chromatography (2:3 methylene chloride/pentane) to give 1-chloromethyl-2-vinyl-benzene as a colorless oil (4.43 g, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05731306 |
|---|
| 出典データセット | uspto-grants-1998_03 |
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| ORD ID | ord-fc7f4a6b6ae94decb6730375d9ad1be0 |
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| 出典メモ | uspto-grants-1998_03 |
|---|
