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4-Chlorobenzenesulfonyl chloride → 3-Cyanomethyl-1-(4-chlorophenylsulfonyl)pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-(Pyrrolidin-3-yl)acetonitrile hydrochloride | HCID 20078139 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-Cyanomethyl-1-(4-chlorophenylsulfonyl)pyrrolidine | HCID 20078166 | 101.1% |
反応手順
Acylation, in chloroform, of 36.6 g (0.25 mol) of 3-cyanomethylpyrrolidine hydrochloride with 52.7 g (0.25 mol) of para-chlorophenylsulfonic acid chloride, in the presence of 50.5 g (0.5 mol) of triethylamine makes it possible to obtain 72 g of a solid which is purified by chromatography on silica, Merck 70-230 mesh, using as eluent a dichloromethane/methanol mixture (99/1 v/v).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05387591 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-f57e2c7f26ac4a6085f3586e6f76abbd |
| 出典メモ | uspto-grants-1995_02 |