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Ethoxyacetic acid → 1-(2-(Ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethoxyacetic acid | HCID 12301 | — |
| 反応物 | 1-((3-Aminoquinolin-4-yl)amino)-2-methylpropan-2-ol | HCID 14986941 | — |
| 生成物 | 1-(2-(Ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol | HCID 22672653 | 6% |
反応手順
Using the general method of Example 91, 3-amino-4-(2-hydroxy-2-methylpropylamino)quinoline (46.2 g. 0.20 mol) was reacted with ethoxyacetic acid (62.5 g, 0.6 mol) to provide 53.6 g of crude product as a greyish solid. A small amount was recrystallized from toluene to provide 3.6 g of a colorless solid, m.p. 117°-120° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389640 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-1dea475a02b7470897920f119ede1a9c |
| 出典メモ | uspto-grants-1995_02 |