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Hydrochloric Acid → 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-(2-Chlorobenzyl)-6-ethoxycarbonyl-2-methylbenzimidazole | HCID 18680839 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole | HCID 18680817 | 99.7% |
反応手順
To 60.0 g of 1-(2-chlorobenzyl)-6-ethoxycarbonyl-2 -methylbenzimidazole were added 240 g of a 10% sodium hydroxide aqueous solution and 200 ml of ethanol, and the mixture was heat-refluxed for 2 hours. The reaction solution was cooled, and was then adjusted to a pH of 6 with 10% hydrochloric acid. The crystals precipitated were separated through filtration, and were dried to give 54.7 g of 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (121).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06352985B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-ae6e4656e61941229b14dc8ec8d70536 |
| 出典メモ | uspto-grants-2002_03 |