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Ethylene Glycol → 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | 4-Chloro-4'-nitrobenzophenone | HCID 347771 | — |
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane | HCID 15489626 | 98% |
反応手順
A mixture of (4-chlorophenyl)(4-nitrophenyl)methanone (0.0382 mol), 1,2-ethanediol (0.0764 mol) and 4-methylbenzenesulfonic acid monohydrate 96% (0.19 mol) in methylbenzene (150 ml) was stirred and refluxed in a Dean Stark apparatus for 24 hours. The mixture was washed with K2CO3 (10%) and then with water. The organic layer was dried, filtered off and evaporated. The product was used without further purification, yielding 11.42 g (98%) of 2-(4-chlorophenyl)-2-(4nitro-phenyl)-1,3-dioxolane (interm. 1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06358961B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-ce8df340b3c24cc6b99b76346f0e797b |
| 出典メモ | uspto-grants-2002_03 |