関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | 3-Bromofuran | HCID 89164 | — |
| 反応物 | N-Methoxy-N,4-dimethyloxazole-5-carboxamide | HCID 18925369 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-Furyl 4-Methyl-5-oxazolyl Ketone | HCID 18936307 | — |
反応手順
3-Bromofuran (2.5 g) in dry diethylether was stirred and cooled to -70° C. under an atmosphere of dry nitrogen and n-butyllithium (2.5M solution in hexane, 6.8 ml) was added dropwise. After 30 minutes, N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (2.89 g) in dry diethylether was added dropwise. After a further 30 minutes the mixture was allowed to warm to room temperature. Ethanol (5 ml) was added followed by saturated aqueous sodium chloride. The mixture was extracted with dichloromethane and the material thus obtained was purified by flash chromatography to give the title compound. M.p. 82°-83.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05731335 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-69d90fe1ebe346e2ad0d74e44a53c346 |
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| 出典メモ | uspto-grants-1998_03 |
|---|
