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Phenylglyoxal → N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-phenyl ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylglyoxal | HCID 14090 | — |
| 反応物 | 3-(Trifluoromethyl)phenylglyoxal | HCID 2783284 | — |
| 反応物 | 2-Methyl-4-(4-methylphenyl)butan-2-amine | HCID 23322167 | — |
| 生成物 | N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-phenyl ethanamine | HCID 23322158 | — |
反応手順
The title compound was prepared in the manner described in Example 9, replacing 2-(4-methylphenyl)-1,1-dimethylethanamine by 3-(4-methylphenyl)-1,1-dimethylpropanamine and 3-trifluoromethylphenyl glyoxal by phenylglyoxal. The chromatographed material was recrystallised from hexane to give the title compound m.p. 107-110. τ (CDCl3) 8.95 (6H, s), 8.2-8.7 (2H, m), 7.8 (3H, s), 7.3-7.7 (4H, m), 5.7-6.5 (2H, m), 5.5 (1H, t, J=6 Hz), 2.9 (4H, s), 2.7 (4H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588749 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-250f6c9aa124474789d01ccb26ee94bd |
| 出典メモ | uspto-grants-1986_05 |