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Water → ethyl 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Hydrazinopyridine | HCID 78645 | — |
| 反応物 | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | ethyl 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate | HCID 742041 | 50.9% |
反応手順
A solution of 21.83 g of 2-hydrazinopyridine and 38.2 g of ethyl(ethoxymethylene)cyanoacetate dissolved in 150 ml of acetic acid and 50 ml of water was heated on a steam bath for approximately 16 hours. The reaction mixture was allowed to cool to room temperature and placed in a refrigerator whereupon crystals slowly formed. The precipitated solid was collected by filtration and washed with cold 50% aqueous ethanol to provide 23.62 g of 5-amino-1-(2-pyridinyl)-1H-pyrazole-4-carboxylic acid, ethyl ester. Yield 50.9%. MP=89°-91° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04589905 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-e7040e39863e4daa9661026a69fbdc7e |
| 出典メモ | uspto-grants-1986_05 |