関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | 2-Furancarboxylic acid | HCID 6919 | — |
| 反応物 | Anisole | HCID 7519 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Potassium Hydroxide | HCID 14797 | — |
| 溶媒 | Sodium | HCID 5360545 | — |
| 生成物 | Dimethyl Sulfate | HCID 6497 | — |
| 生成物 | 2-Hydroxy-1-naphthoic acid | HCID 16790 | — |
| 生成物 | Methyl 2-methoxy-1-naphthoate | HCID 604022 | — |
反応手順
This methyl ester was previously made by fusion of anisole and 2-furoic acid followed by esterification of the acid intermediate, J. Amer. Chem. Soc., Vol. 69, 2261 (1947). Methyl esters of methoxy carboxylic acids were prepared by methylation of aromatic hydroxy carboxylic acids with dimethyl sulfate in the presence of potassium carbonate as base, using acetone as the solvent, Houben-Weyl, Methoden der Organischen Chemie., Vol. 8, 542-3 (1952). Methylation of 2-hydroxy-1-naphthoic acid with dimethyl sulfate in aqueous sodium or potassium hydroxide produced mainly methyl-2-methoxy-1-naphthalenecarboxylate, Chemische Berichte, Vol. 37, 3658-61 (1904). In aqueous solutions, at pH 4-6.5, methylation of hydroxy napthoic acids with dimethyl sulfate produced the methyl esters of the hydroxy naphthoic acids.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04590290 |
|---|
| 出典データセット | uspto-grants-1986_05 |
|---|
| ORD ID | ord-c324ab068a684be1923eb42b45f5f752 |
|---|
| 出典メモ | uspto-grants-1986_05 |
|---|
