関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-(Chloromethyl)pyridine | HCID 74571 | — |
| 反応物 | HCID 178432453 | HCID 178432453 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | isopropyl N-(4-pyridylmethyl)-2-bromo-4-methyl-5-imidazole carboxylate | HCID 13633307 | 92% |
反応手順
To a suspension of 195 milligrams (mg) (8.13 mM) of sodium hydride in 20 ml of anhydrous tetrahydrofuran was added, in portions, 2 g (8.13 mM) of isopropyl 2-bromo-4-methyl-5-imidazolecarboxylate. The resulting suspension was cooled to 0° C. and 1.03 g (8.13 mM) of 4-chloromethylpyridine was added. The reaction mixture was stirred overnight at 50° C. The precipitated sodium chloride was removed by filtration and concentration in vacuo of the filtrate gave 2.5 g (92%) of isopropyl N-(4-pyridylmethyl)-2-bromo-4-methyl-5-imidazole carboxylate as a tan solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04591377 |
|---|
| 出典データセット | uspto-grants-1986_05 |
|---|
| ORD ID | ord-dbb495aba34848dc857773c0f1cfbd27 |
|---|
| 出典メモ | uspto-grants-1986_05 |
|---|
