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Sodium Carbonate → 8-Amino-1-tetralone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-1-YL)acetamide | HCID 12119265 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 8-Amino-1-tetralone | HCID 11400942 | 56% |
反応手順
The amide (Intermediate J2, 4.12 g, 20.3 mmol) was heated at 90° C. in 6N HCl (140 mL) for 3 h. The mixture was cooled to rt and Na2CO3 was added in small portions followed by addition of 2N NaOH until the mixture was at pH 8. The aqueous layer was extracted with EtOAc and the organic fractions were combined, washed with brine, dried, filtered and concentrated to give 8-amino-3,4-dihydro-2H-naphthalen-1-one (Intermediate J3) as a dark red solid 1.82 g (56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419994B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-d4ee0d53e18d4ca895631cd50a28c647 |
| 出典メモ | uspto-grants-2008_09 |