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Phenyl isocyanate → HCID 46885625、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl isocyanate | HCID 7672 | — |
| 反応物 | 4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline | HCID 68999813 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | HCID 46885625 | HCID 46885625 | 50% |
反応手順
A solution of 4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline (2.2 mmol) in pyridine (4 mL) was treated with phenyl isocyanate (2.4 mmol) and stirred for 1 h at room temperature. The reaction mixture was concentrated in vacuo and purification of the residue by flash chromatography (80-100% ethyl acetate/hexanes) provided the title product as a white powder (50%). ESMS [M+H]+: 423.2
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419988B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-3345a5a4f2d4456184dba05ed39839ee |
| 出典メモ | uspto-grants-2008_09 |