関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dichlorobenzene | HCID 4685 | — |
| 反応物 | 3-Methylbenzoyl chloride | HCID 74375 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | (2,5-Dichlorophenyl)(3-methylphenyl)methanone | HCID 18704036 | 53% |
反応手順
A mixture of m-toluoyl chloride (22 g, 0.17 mol) and 1,4-dichlorobenzene (120 g, 0.82 mol) was heated to 100° C. in a flask. Aluminum chloride (60 g, 0.45 mol) was added in one portion. Hydrogen chloride started to evolve from the solution. The mixture was heated to 170° C. in 30 min. and stirred at this temperature for 3 hours. The resulting brownish solution was cooled to about 80° C. and poured onto ice. Ether (50 ml) was added. The organic layer was separated and distilled under vacuum after the removal of ether. The residue from distillation was recrystallized twice from hexane to give 20 g of white crystals (53%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05731400 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-4ed142657f3d431e82ca203fc86540a6 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
