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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 3-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734624 | — |
| 反応物 | 2-Chloromethyl-3-methyl-benzofuran | HCID 10261721 | — |
| 生成物 | 3-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran | HCID 67110429 | 44% |
反応手順
Alkylation of 2-chloromethyl-3-methyl-benzofuran with 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol was carried out according to Example 136, Step 3, to give 3-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran in 44% yield. 1H NMR (400 MHz, CDCl3) δ ppm 1.3 (s, 12 H) 2.3 (s, 3 H) 5.2 (s, 2 H) 7.0 (d, J=8.6 Hz, 2 H) 7.3 (m, 2 H) 7.5 (dd, J=21.6, 7.7 Hz, 2 H) 7.8 (d, J=8.8 Hz, 2 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07420001B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-a8e446d0bead4eb8840052f10d71c806 |
| 出典メモ | uspto-grants-2008_09 |