化工社化工社 化学情報印刷レポート · 研究参考用
1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → 4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine | HCID 4184869 | — |
| 反応物 | BEMP resin | HCID 16216994 | — |
| 反応物 | 4-[1-(4-chloro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68530176 | — |
| 反応物 | HCID 178518865 | HCID 178518865 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68532836 | 51% |
反応手順
4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 46) was prepared as described above for Intermediate 42 using Intermediate 45 (300 mg, 1.218 mmol), PS-BEMP resin (1.108 g) and 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 2) (374 mg, 1.34 mmol) in DMF (10 ml) to afford 265 mg (51%) of Intermediate 46 as a yellow oil. MS (M+1)=430.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423054B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-150fdb8a77df4999909115a7edd9ba62 |
| 出典メモ | uspto-grants-2008_09 |