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Acetic Acid → Diethyl 2-[(3-formylphenyl)methylene]propane-1,3-dioate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Isophthalaldehyde | HCID 34777 | — |
| 反応物 | 2,2-Diethylpropanedioate | HCID 6951563 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Diethyl 2-[(3-formylphenyl)methylene]propane-1,3-dioate | HCID 59789754 | — |
反応手順
Benzene 1,3 dicarbaldehyde (1 eq) is dissolved in toluene, and diethylmalonate (1 eq) is added, followed by piperidine (0.1 eq) and AcOH (0.1 eq). The flask is equipped with a Dean Stark trap and the reaction mixture is refluxed overnight. The reaction mixture is cooled down to room temperature, washed with water, 2% aq HCl, sat. aq NaHCO3, brine, and dried. The solvent is evaporated under reduced pressure and the product 32 is isolated by column chromatography on silicagel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423148B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-fd79de5b16c441b29e7acf5015ddc480 |
| 出典メモ | uspto-grants-2008_09 |