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Potassium Carbonate → 3-Amino-2-(1-[3,4-dimethylphenylcarbonylmethyl]benzimidazol-2-yl)-1,2,4-triazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(1H-Benzoimidazol-2-YL)-2H-[1,2,4]triazol-3-ylamine | HCID 608264 | — |
| 反応物 | 2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one | HCID 3703113 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Amino-2-(1-[3,4-dimethylphenylcarbonylmethyl]benzimidazol-2-yl)-1,2,4-triazole | HCID 11233278 | — |
反応手順
A suspension of 3-amino-2-(1H-benzimidazol-2-yl)-1,2,4-triazole (0.15 g, 0.75 mol), 3,4-dimethyl phenacyl bromide (0.204 g, 0.9 mmol) and dry potassium carbonate (0.258 g, 1.87 mmol) is stirred at room temperature for 16 hours. The mixture is diluted with water and the product extracted with ethyl acetate. The product is purified by chromatography on silicagel. M.p. 190-193° C., 1H-NMR (400 MHz, d6-DMSO): 7.84 (m, 1H); 7.77 (m, 3H); 7.65 (m, 2H); 7.50 (s, 1H); 7.33 (d, 1H); 6.22 (s, 2H); 2.30 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423157B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-ecd8d20f50624f239d7c702deaa50531 |
| 出典メモ | uspto-grants-2008_09 |