化工社化工社 化学情報印刷レポート · 研究参考用
2-Acetylhydroquinone → 6-Hydroxy-2-(2,6-Difluorophenyl)chroman-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Acetylhydroquinone | HCID 10279 | — |
| 反応物 | 2,6-Difluorobenzaldehyde | HCID 136284 | — |
| 反応物 | 2-(3-Fluorophenyl)-6-hydroxychroman-4-one | HCID 17978465 | — |
| 生成物 | 6-Hydroxy-2-(2,6-Difluorophenyl)chroman-4-one | HCID 17978454 | — |
反応手順
6-Hydroxy-2-(2,6-Difluorophenyl)chroman-4-one was prepared as described for 2-(3-fluorophenyl)-6-hydroxychroman-4-one in Example 9(a) starting from 3.0 g of 2′,5′-dihydroxyacetophenone and 2.6 ml of 2,6-difluorobenzaldehyde. The product was triturated from ethanol. 1H NMR (400 MHz, d6-DMSO) δ: 7.55 (m, 1H) 7.22-7.18 (m, 2H), 7.14 (d, 1H, J 3.0 Hz), 7.03 (dd, 1H, J 8.9, 3.0 Hz), 6.93 (d, 1H, J 8.9 Hz), 5.84 (dd, 1H, J 14.0, 3.0 Hz), 3.38 (dd, 1H, J −17.0, 14.0 Hz), 2.80 (dd, 1H, J −17.0, 3.0 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425568B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-029755eaf6674aaa9055d0c61af1b24c |
| 出典メモ | uspto-grants-2008_09 |