化工社化工社 化学情報印刷レポート · 研究参考用
p-Tolylacetic acid → N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Tolylacetic acid | HCID 248474 | — |
| 反応物 | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| 生成物 | N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester | HCID 22492098 | — |
反応手順
Following General Procedure B′ and using 4methylphenylacetic acid (Aldrich) and D,L-alanine isobutyl ester hydrochloride (from Example B′ above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211235B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-465535fa819a4224bee6543aa6309387 |
| 出典メモ | uspto-grants-2001_04 |