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Triethylamine → 3-Iodo-N-methoxy-N-methylbenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Iodobenzoyl chloride | HCID 74378 | — |
| 反応物 | 1-Methoxymethanamine | HCID 17778177 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Iodo-N-methoxy-N-methylbenzamide | HCID 22322052 | — |
反応手順
A stirred solution of N-methoxymethylamine (3.47 g) and triethylamine (10.4 mL) in dichloromethane (100 mL) at 5° C. is treated dropwise with 3-iodobenzoyl chloride (9.8 g). The reaction mixture is stirred at room temperature for 2 hours, washed twice with water (70 mL), dried over magnesium sulphate, and evaporated to give N-methoxy-N-methyl-3-iodobenzamide (9.8 g) as a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211234B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-e480a71bec5f485ab375837bfa47cb72 |
| 出典メモ | uspto-grants-2001_04 |