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Furfural → 2-[2-(2-Furyl)ethenyl]-8-quinolinol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Furfural | HCID 7362 | — |
| 反応物 | 2-Methyl-8-hydroxyquinoline | HCID 13224 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-[2-(2-Furyl)ethenyl]-8-quinolinol | HCID 54571506 | — |
反応手順
A mixture of 8-hydroxyquinaldine (5.09 g) and 2-furaldehyde (8.0 mL) are heated at reflux overnight. The reaction is cooled to room temperature. The residue is taken up in acetone and adsorbed onto silica. A silica gel column eluting with 100% CH2Cl2 is run and the product-containing fractions evaporated under reduced pressure to give an orange/yellow oil. The product is crystallized with EtOH/H2O, filtered, washed thoroughly with water, and dried (1.18 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211376B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-8d25002f24364c09889727a74d4f2bb0 |
| 出典メモ | uspto-grants-2001_04 |